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Nucleic Acids Research, 1986, Vol. 14, No. 14 5901-5918
© 1986

Articles

Nudeotide sequence of the intracisternal A-particle genome Inserted 5' to the lnterleukin-3 gene of the leukaemia cell line WEHI-3B

Sanie Ymer, William Q.J. Tucker, Hugh D. Campbell and Ian G. Young

Medical Molecular Biology Unit, John Curtin School of Medical Research, Australian National University PO Box 334, Canberra, ACT 2601, Australia

Received April 29, 1986. Revised June 16, 1986. Accepted June 23, 1986.

The nucleotide sequence of the intracisternal A-particle genome IAP-IL3 is presented. This IAP element was found to have inserted upstream of the promoter of the interleukin-3 gene of the leukaemia cell line WEHI-3B. IAP-IL3 is 5095 bp in length, with identical long terminal repeats (LTRs) of 337 bp. The LTRs show many of the conserved sequence elements identified in other retroviruses. Comparison with other available sequences of IAP genomes indicates that IAP-IL3 is a deleted type I element. It carries a deletion covering the 3' end of the putative IAP gag gene and extending into the 5' end of the putative IAP polgene. IAP-IL3 has extensive sequence homology with an IgE-binding factor cDNA and evidence is presented indicating that it was derived from a member of the mouse IAP sequence family. Comparison between the polregion of IAP-IL3 and other retroviruses suggests that IAP-IL3 is most closely related to type B and type D retroviruses.


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