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Nucleic Acids Research, 1986, Vol. 14, No. 16 6345-6355
© 1986

Articles

Diversity in G+C content at the third position of codons in vertebrate genes and its cause

Shin-ichi Aota and Toshimichi Ikemura

DNA Research Center, National Institute of Genetics Mishima 411, Japan

Received June 24, 1986. Accepted July 29, 1986.

Correlation was positive between the G+C content at the codon third position in genes of vertebrates and the G+C content of the genome portion surrounding each gene. Exons of genes with a high G+C% at the codon 3rd position are surrounded by G+C-rich introns and G+C-rich flanking sequences, and those with a low G+C% at the position by A+T-rich introns and flanking sequences. Analysis of G+C content distribution along DNA sequences using a DNA Sequence Data Bank supported the view that the vertebrate genome is a mosaic of regions with clear differences in their G+C content. biological significance of thevariation in G+C content throughout the vertebrate genome is discussed in connection with chromosomal banding.


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