Nucleic Acids Research, 1986, Vol. 14, No. 17 7017-7029
© 1986
Articles |
ß-Thalassaemias 1 and 2 are the result of a 100 kbp deletion in the human ß-globin cluster
Laboratory of Gene Structure and Expression, National Institute for Medical Research The Ridgeway, Mill Hill, London NW7 1AA, UK
Received July 3, 1986. Accepted August 11, 1986.
The DNA spanning two large deletions in the human ß-globin gene cluster (
ß-thalassaemia 1 and 2) has been cloned by cosmid cloning and chromosomal walking. The entire region was mapped and analyzed for the presence of repetitive sequences. The results show that the affected loci have lost almost 100kb of DNA in a deletion event not involving homologous or repetitive sequences.
1Present address: Rockefeller University, 1230 York Avenue, New York
2Present address: Ohio State University, 484 N-12th Street, Colombus, OH 43210, USA
3Present address: Erasmus University, Postbox 1738, 3000 DR Rotterdam The Netherlands
4Present address: Oncogene Science Inc, 222, Station Plaza North, Mineola, NY 11501, USA
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