Skip Navigation

This Article
Right arrow Print PDF (300K)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (236)
Right arrowRequest Permissions
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Bonner, T. I.
Right arrow Articles by Rapp, U. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bonner, T. I.
Right arrow Articles by Rapp, U. R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1986, Vol. 14, No. 2 1009-1015
© 1986

Articles

The complete coding sequence of the human raf oncogene and the corresponding structure of the c-raf-1 gene

Tom I. Bonner, Hermann Oppermann1, Peter Seeburg1, Stephen B. Kerby2, Mark A. Gunnell2, Alice C. Young and Ulf R. Rapp3

Laboratory of Cell Biology, National Institute of Mental Health Bethesda, MD 20205, USA 1Department of Molecular Biology, Genentech Inc South San Francisco, CA 94080, USA 2Program Resources Inc., Frederick Cancer Research Facility Frederick, MD 21701, USA 3Laboratory of Viral Carcinogenesis, National Cancer Institute Frederick, MD 21701, USA

Received October 21, 1985. Revised December 4, 1985. Accepted December 16, 1985.

The complete 648 amlno acid sequence of the human raf oncogene was deduced from the 2977 nucleotide sequence of a fetal liver cDNA. The cDNA has been used to obtain clones which extend the human c-raf-1 locus by an additional 18.9 kb at the 5' end and contain all the remaining coding exons.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Mol Cancer ResHome page
J. Borlak and H. S. Jenke
Cross-talk between Aryl Hydrocarbon Receptor and Mitogen-Activated Protein Kinase Signaling Pathway in Liver Cancer through c-raf Transcriptional Regulation
Mol. Cancer Res., August 1, 2008; 6(8): 1326 - 1336.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
A. V. Oleinikov, J. Zhao, and M. D. Gray
RNA interference by mixtures of siRNAs prepared using custom oligonucleotide arrays
Nucleic Acids Res., June 7, 2005; 33(10): e92 - e92.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Hekman, S. Wiese, R. Metz, S. Albert, J. Troppmair, J. Nickel, M. Sendtner, and U. R. Rapp
Dynamic Changes in C-Raf Phosphorylation and 14-3-3 Protein Binding in Response to Growth Factor Stimulation: DIFFERENTIAL ROLES OF 14-3-3 PROTEIN BINDING SITES
J. Biol. Chem., April 2, 2004; 279(14): 14074 - 14086.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
M. L. Gandara, P. Lopez, R. Hernando, J. G. Castano, and S. Alemany
The COOH-Terminal Domain of Wild-Type Cot Regulates Its Stability and Kinase Specific Activity
Mol. Cell. Biol., October 15, 2003; 23(20): 7377 - 7390.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
V. Hsu, C. L. Zobel, E. J. Lambie, T. Schedl, and K. Kornfeld
Caenorhabditis elegans lin-45 raf Is Essential for Larval Viability, Fertility and the Induction of Vulval Cell Fates
Genetics, February 1, 2002; 160(2): 481 - 492.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
Q.-H. Zhang, M. Ye, X.-Y. Wu, S.-X. Ren, M. Zhao, C.-J. Zhao, G. Fu, Y. Shen, H.-Y. Fan, G. Lu, et al.
Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells
Genome Res., October 1, 2000; 10(10): 1546 - 1560.
[Abstract] [Full Text]

Home page
 Mol. Cell. Biol.Home page
Y. Takatsu, M. Nakamura, M. Stapleton, M. C. Danos, K. Matsumoto, M. B. O'Connor, H. Shibuya, and N. Ueno
TAK1 Participates in c-Jun N-Terminal Kinase Signaling during Drosophila Development
Mol. Cell. Biol., May 1, 2000; 20(9): 3015 - 3026.
[Abstract] [Full Text]

Home page
 Cell Growth Differ.Home page
E. Kerkhoff, L. M. Fedorov, R. Siefken, A. O. Walter, T. Papadopoulos, and U. R. Rapp
Lung-targeted Expression of the c-Raf-1 Kinase in Transgenic Mice Exposes a Novel Oncogenic Character of the Wild-Type Protein
Cell Growth Differ., April 1, 2000; 11(4): 185 - 190.
[Abstract] [Full Text]

Home page
 BloodHome page
A. Arai, Y. Nosaka, H. Kohsaka, N. Miyasaka, and O. Miura
CrkL Activates Integrin-Mediated Hematopoietic Cell Adhesion Through the Guanine Nucleotide Exchange Factor C3G
Blood, June 1, 1999; 93(11): 3713 - 3722.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
C. WIDMANN, S. GIBSON, M. B. JARPE, and G. L. JOHNSON
Mitogen-Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human
Physiol Rev, January 1, 1999; 79(1): 143 - 180.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. Papin, A. Denouel-Galy, D. Laugier, G. Calothy, and A. Eychene
Modulation of Kinase Activity and Oncogenic Properties by Alternative Splicing Reveals a Novel Regulatory Mechanism for B-Raf
J. Biol. Chem., September 18, 1998; 273(38): 24939 - 24947.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
R. E. Cutler Jr., R. M. Stephens, M. R. Saracino, and D. K. Morrison
Autoregulation of the Raf-1 serine/threonine kinase
PNAS, August 4, 1998; 95(16): 9214 - 9219.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Shirouzu, K. Morinaka, S. Koyama, C.-D. Hu, N. Hori-Tamura, T. Okada, K.-i. Kariya, T. Kataoka, A. Kikuchi, and S. Yokoyama
Interactions of the Amino Acid Residue at Position 31 of the c-Ha-Ras Protein with Raf-1 and RalGDS
J. Biol. Chem., March 27, 1998; 273(13): 7737 - 7742.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. Houssa, D. Schaap, J. van der Wal, K. Goto, H. Kondo, A. Yamakawa, M. Shibata, T. Takenawa, and W. J. van Blitterswijk
Cloning of a Novel Human Diacylglycerol Kinase (DGKtheta ) Containing Three Cysteine-rich Domains, a Proline-rich Region, and a Pleckstrin Homology Domain with an Overlapping Ras-associating Domain
J. Biol. Chem., April 18, 1997; 272(16): 10422 - 10428.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
J D Ceci, C P Patriotis, C Tsatsanis, A M Makris, R Kovatch, D A Swing, N A Jenkins, P N Tsichlis, and N G Copeland
Tpl-2 is an oncogenic kinase that is activated by carboxy-terminal truncation.
Genes & Dev., March 15, 1997; 11(6): 688 - 700.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
J. P. Irigoyen, D. Besser, and Y. Nagamine
Cytoskeleton Reorganization Induces the Urokinase-type Plasminogen Activator Gene via the Ras/Extracellular Signal-regulated Kinase (ERK) Signaling Pathway
J. Biol. Chem., January 17, 1997; 272(3): 1904 - 1909.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Ueda, S. Hirai, S. Osada, A. Suzuki, K. Mizuno, and S. Ohno
Protein kinase C activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf
J. Biol. Chem., September 20, 1996; 271(38): 23512 - 23519.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. M. Klauck, X. Xu, B. Mousseau, and S. Jaken
Cloning and Characterization of a Glucocorticoid-induced Diacylglycerol Kinase
J. Biol. Chem., August 16, 1996; 271(33): 19781 - 19788.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
K. Yamaguchi, K. Shirakabe, H. Shibuya, K. Irie, I. Oishi, N. Ueno, T. Taniguchi, E. Nishida, and K. Matsumoto
Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-beta Signal Transduction
Science, December 22, 1995; 270(5244): 2008 - 2011.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
Y.-H. Chow, K. Pumiglia, T. H. Jun, P. Dent, T. W. Sturgill, and R. Jove
Functional Mapping of the N-terminal Regulatory Domain in the Human Raf-1 Protein Kinase
J. Biol. Chem., June 9, 1995; 270(23): 14100 - 14106.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. W. M. Reuter, A. D. Catling, T. Jelinek, and M. J. Weber
Biochemical Analysis of MEK Activation in NIH3T3 Fibroblasts
J. Biol. Chem., March 31, 1995; 270(13): 7644 - 7655.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. Herrmann, G. A. Martin, and A. Wittinghofer
Quantitative Analysis of the Complex between p21[IMAGE] and the Ras-binding Domain of the Human Raf-1 Protein Kinase
J. Biol. Chem., February 17, 1995; 270(7): 2901 - 2905.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
G. Martin, S. Brommonschenkel, J Chunwongse, A Frary, M. Ganal, R Spivey, T Wu, E. Earle, and S. Tanksley
Map-based cloning of a protein kinase gene conferring disease resistance in tomato
Science, November 26, 1993; 262(5138): 1432 - 1436.
[Abstract] [PDF]

Home page
 Genome ResHome page
A Rashtchian, C G Thornton, and G Heidecker
A novel method for site-directed mutagenesis using PCR and uracil DNA glycosylase.
Genome Res., November 1, 1992; 2(2): 124 - 130.
[Abstract] [PDF]

Home page
 Genes Dev.Home page
J T Bruder, G Heidecker, and U R Rapp
Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase.
Genes & Dev., April 1, 1992; 6(4): 545 - 556.
[Abstract] [PDF]

Home page
 Genome ResHome page
M Jung, A Dritschilo, and U Kasid
Reliable and efficient direct sequencing of PCR-amplified double-stranded genomic DNA template.
Genome Res., February 1, 1992; 1(3): 171 - 174.
[Abstract] [PDF]

Home page
 ScienceHome page
Hubbard SR, W. Bishop, P Kirschmeier, S. George, S. Cramer, and W. Hendrickson
Identification and characterization of zinc binding sites in protein kinase C
Science, December 20, 1991; 254(5039): 1776 - 1779.
[Abstract] [PDF]

Home page
 ScienceHome page
U Kasid, A Pfeifer, T Brennan, M Beckett, R. Weichselbaum, A Dritschilo, and G. Mark
Effect of antisense c-raf-1 on tumorigenicity and radiation sensitivity of a human squamous carcinoma
Science, March 10, 1989; 243(4896): 1354 - 1356.
[Abstract] [PDF]

Home page
 ScienceHome page
S. Hanks, A. Quinn, and T Hunter
The protein kinase family: conserved features and deduced phylogeny of the catalytic domains
Science, July 1, 1988; 241(4861): 42 - 52.
[Abstract] [PDF]

Home page
 ScienceHome page
U Kasid, A Pfeifer, R. Weichselbaum, A Dritschilo, and G. Mark
The raf oncogene is associated with a radiation-resistant human laryngeal cancer
Science, August 28, 1987; 237(4818): 1039 - 1041.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
K. H. Cox, R. Rai, M. Distler, J. R. Daugherty, J. A. Coffman, and T. G. Cooper
Saccharomyces cerevisiae GATA Sequences Function as TATA Elements during Nitrogen Catabolite Repression and When Gln3p Is Excluded from the Nucleus by Overproduction of Ure2p
J. Biol. Chem., June 2, 2000; 275(23): 17611 - 17618.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.