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Nucleic Acids Research, 1986, Vol. 14, No. 2 1107-1126
© 1986

Articles

NMR, CD and IR spectroscopies of a tridecanucieotide containing a no-base residue: coexistence of B and Z conformations

Sylvie Pochet, Tam Huynh-Dinh, Jean-Michel Neumann1, Son Tran-Dinh1, Safia Adam2, Jean Taboury2, Eliane Taillandier2 and Jean Igolen*

Unité de Chimie Organique, UA-CNRS 487, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex, France 1Service de Biophysique, Centre d'Etudes Nucléaires de Saclay, 91191 Gif-sur-Yvette Cedex, France 2Laboratoire de Spectroscopie Biomoléculaire, UER Médecine-Biologie, 74, rue Marcel Cachin, 93012 Bobigny Cedex, France

*To whom correspondence should be addressed

Received August 30, 1985. Revised November 18, 1985. Accepted December 17, 1985.

The synthesis of the tridecadeoxynucleotide d(CGm5CGCGxACATGT), where x is the 1-cyano-2-deoxy-B-D-erythropentofuranose, is described. The NMR, IR, CD studies at various salt concentrations and temperatures of this oligomer show that the B and Z conformations are simultaneously present in the same short DNA fragment. A single apurinic residue is sufficent for the coexistence of the B and Z helices on this oligomer.


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