Nucleic Acids Research, 1986, Vol. 14, No. 2 623-633
© 1986
Articles |
Amino acid sequence homology in gag region of reverse transcribing elements and the coat protein gene of cauliflower mosaic virus
Department of Virus Research, John Innes Institute Colney Lane, Norwich NR4 7UH, UK
Received October 25, 1985. Accepted December 10, 1985.
A nucleic acid binding protein (NBP) derived from the gag gene of retroviruses that is thought to interact with genomic RNA in virion cores, contains a highly conserved arrangement of cysteine residues. A search of available nucleic acid and protein sequences has revealed that the motif CysX2CysX4HisX4Cys (NBPcys) is invarlent in all replication competent retroviruses, a Syrian hamster intracisternal A-particle gene, the Drosophila retrotransposon copia and in cauliflower mosaic virus (CaMV). In each case, NBPcys is located in that part of the ‘gag-pol’ region Just preceding a conserved protease amino acid sequence. This is of special significance for CaMV as NBPcys is in the coat protein gene (ORF IV) upstream of the putative reverse transcrlptase gene (ORF V) and demonstrates that the gag-pol arrangement of reverse transcribing elements is preserved in CaMV. Moreover, CaMV differs from all other known NBPcys-con-taining elements in that it packages a DNA genome in virions.
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