Nucleic Acids Research, 1986, Vol. 14, No. 20 7883-7896
© 1986
Articles |
Isolation and sequence of a human gene encoding a potent inhibitor of leukocyte proteases
Synergen, Inc. 1885 33rd Street, Boulder, CO 80301, USA
Received July 14, 1986. Accepted September 23, 1986.
We report the isolation of the human gene encoding an inhibitor of neutrophil elastase and cathepsin G. We have sequenced the gene and a cDNA clone isolated from human parotid tissue. The protein encoded by this gene appears to contain two functional domains, one having a trypsin inhibitory site and the other an elastase inhibitory site. The two-domain structure of the protein is reflected in the organization of the gene, with each domain represented by a separate exon. We have also noted that the intervening sequence separating the trypsin-inhibitor-exon and the elastase-inhibitor-exon is flanked by eleven base-pair direct repeats, suggesting that this intron may have been generated by a transposition-type event.
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