Nucleic Acids Research, 1986, Vol. 14, No. 20 7897-7914
© 1986
Articles |
Genomic sequence for human prointerleukin 1 beta: possible evolution from a reverse transcribed prointerleukin 1 alpha gene
1Harvard-M.I.T. Division of Health Sciences and Technology Cambridge, MA 02139 2Department of Biological Sciences, Wellesley College Wellesley, MA 02181 3Department of Medicine, The New England Medical Center-Tufts University School of Medicine Boston, MA 02111, USA
Received July 10, 1986. Accepted September 16, 1986.
We have isolated the human prointerleukin 1 (proIL-1) beta gene from leukocyte and fetal liver libraries. The nucleotide sequence and its gene organization reveals that the proIL-1ß gene is composed of seven exons with a primary transcription product length of 7, 008 nucleotides. The exon sequence agrees well with that of the human proIL-10 cDNA. Features of interest within the transcriptional unit include conventionally positioned TATA, CAT, and poly-adenylation signals for gene regulation, as well as the signatures of gene duplication via retrotransposition in the form of flanking direct repeats and a genoraic poly A tail. The genomic organization of the proIL-1ß gene with respect to the number and position of exon boundaries is strikingly similar to that of the recently reported human proIL-1
gene. Therefore, we hypothesize that the proIL-1ß may have arisen by a reverse transcriptase mediated duplication of the related alpha gene.
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