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Nucleic Acids Research, 1986, Vol. 14, No. 20 7929-7937
© 1986

Articles

A variable tandem repeat locus mapped to chromosome band 10q26 is amplified and rearranged in leukocyte DNAs of two cancer patients

Mark Colb1,2, Teresa Yang-Feng3, Uta Francke3, Brion Mermer1,2, David R. Parkinson1 and Theodore G. Krontiris1,2,*

1Department of Medicine (Hematology/Oncology), Tufts-New England Medical Center 2Department of Molecular Biology and Microbiology, Tufts University School of Medicine Boston, MA 3Department of Human Genetics, Yale University School of Medicine New Haven, CT, USA

*To whom correspondence and reprint requests should be addressed: Division of Hematology/Oncology, New England Medical Center, Box 245, 750 Washington St., Boston MA 02111, USA

Received July 3, 1986. Accepted September 25, 1986.

A highly polymorphic locus associated with the variable tandem repetition of a 35 bp consensus sequence was mapped to chromosome 10, band q26. Examination of leukocyte DNA from a cancer patient revealed the twenty-fold amplification of one allelic fragment of this locus, while the other allelic fragment demonstrated a normal copy number. In another patient, Southern blotting of leukocyte DNA detected the deletion of the 3'-flanking region from one tandem repeat allele. These results indicate that variable tandem repeats may mark highly unstable regions of DNA in the human genome which can be altered by changes more extensive than simple tandem repeat variation.


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