Nucleic Acids Research, 1986, Vol. 14, No. 21 8331-8346
© 1986
Articles |
Transcriptional arrest within the first exon is a fast control mechanism in c-myc gene expression
Institut für Virologie, Zentrum für Hygiene der Universität Freiburg Hermann-Herder-Str. 11, 7800 Freiburg, FRG
Received August 31, 1986. Revised October 3, 1986. Accepted October 3, 1986.
DMSO (dimethylsulfoxide), a potent inducer of granulocytic differentiation in HL60 cells, causes a rapid decrease of cytoplasmic steady state c-myc RNA. This decrease is regulated mainly at the level of transcript elongation. Elongation is blocked within the untranslated c-myc leader. Twelve hours after transcriptional shut off of c-myc, DNAase I hypersensitive site II was still detectable, indicating that closing of this site upstream of the gene does not correlate with reduction in the steady state level of c-myc RNA.
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