Nucleic Acids Research, 1986, Vol. 14, No. 22 9095-9102
© 1986
Articles |
Multiple sequence alignment by consensus
Departments of Mathematics and Molecular Biology, University of Southern California Los Angeles, CA 90089-1113, USA
Received September 16, 1986. Revised October 20, 1986. Accepted October 20, 1986.
An algorithm for multiple sequenoe alignment is given that matches words of length and degree of mismatch chosen by the user. The alignment maximizes an alignment scoring function. The method is based on a novel extension of our consensus sequence methods. The algorithm works for both DNA and protein sequences, and from earlier work on consensus sequences, it is possible to estimate statistical signifioance.
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