Nucleic Acids Research, 1986, Vol. 14, No. 23 9397-9406
© 1986
Articles |
Human lecithin-cholesterol acyltransferase gene: complete gene sequence and sites of expression
Department of Molecular Biology, Genentech Inc. 460 Point San Bruno Boulevard, South San Francisco, CA 94080 *Cardiovascular Research Institute and Department of Physiology, University of California San Francisco, CA 94143, USA
Received August 14, 1986. Accepted October 31, 1986.
The human lecithin-cholesterol acyltransferase (LCAT) gene has been sequenced to completion. The gene is divided into six exons spanning 
4, 200 bp. Exon five codes for amino acids homologous to the interfacial active site of several lipases, and also codes for an amphipathic 
-helix resembling the carboxy terminus of apolipoprotein E. Blot hybridization data suggest that there is only one LCAT gene in humans. The 1550 base LCAT mRNA can be detected in liver and HepG2 (hepatocyte) cells, but not in small intestine, spleen, pancreas, placenta or adrenal tissue.
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