Skip Navigation

This Article
Right arrow Print PDF (592K)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (55)
Right arrowRequest Permissions
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Maguire, D. J.
Right arrow Articles by Elliott, W. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Maguire, D. J.
Right arrow Articles by Elliott, W. H.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1986, Vol. 14, No. 3 1379-1391
© 1986

Articles

Nudeotide sequence of the chicken 5-aminolevulinate synthase gene

Deborah J. Maguire, Adrienne R. Day, Iain A. Borthwick, Gopesh Srivastava, Peter L. Wigley, Brian K. May and William H. Elliott

Adelaide University Centre for Gene Technology, Commonwealth Special Research Centre, Department of Biochemistry, University of Adelaide South Australia

Received December 10, 1985. Accepted January 17, 1986.

5-Aminolevul inate synthase, the first and rate-controlling enzyme of heme biosynthesis, is regulated in the liver by the end-product heme. To study this negative control mechanism, we have isolated the chicken gene for ALA-synthase and determined the nucleotide sequence. The structural gene is 6.9 kb long and contains 10 exons. The transcriptional start site for ALA-synthase was determined by primer extension analysis. A fragment of 291 bp from the 5' flanking region including 34 bp of the first exon shows promoter activity when introduced upstream of a chicken hi stone H2B gene and injected into the nuclei of Xenopus laevis oocytes.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
K. H. Surinya, T. C. Cox, and B. K. May
Transcriptional Regulation of the Human Erythroid 5-Aminolevulinate Synthase Gene. IDENTIFICATION OF PROMOTER ELEMENTS AND ROLE OF REGULATORY PROTEINS
J. Biol. Chem., October 17, 1997; 272(42): 26585 - 26594.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.