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Nucleic Acids Research, 1987, Vol. 15, No. 1 219-232
© 1987

Articles

Synthesis of decadeoxyribonucleotides containing N6-methyladenine, N4-methylcytosine, and 5-methylcytosine: recognition and cleavage by restriction endonucleases (nucleosides and nucleotides part 74)1

Akira Ono and Tohru Ueda*

Faculty of Pharmaceutical Sciences, Hokkaido University Kita-12, Nishi-6, Kita-ku Sapporo 060, Japan

*To whom correspondence should be addressed

Received November 17, 1986. Accepted December 12, 1986.

The naturally-occurring modified bases, N6-methyladenine, N4-methylcytosine, and 5-methylcytosine were chemically introduced in place of the adenine or cytosine in the decadeoxyribonucleotides containing recognition sequences of Bgl II, Sau 3AI, Mbo I and Mfl I. The modified oligomers bind to the enzymes but the rates of cleavage by the enzymes are variable.


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