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Nucleic Acids Research, 1987, Vol. 15, No. 10 3961-3976
© 1987

Articles

Nucleotide sequence analysis of the L gene of Newcastle disease virus: homologies with Sendai and vesicular stomatitis viruses

Khatijah Yusoff, Neil S. Millar, Philip Chambers and Peter T. Emmerson

Department of Biochemistry, The University Newcastle upon Tyne NE1 7RU, UK

Received March 11, 1987. Revised April 23, 1987. Accepted April 23, 1987.

The nucleotide sequence of the L gene of the Beaudette C strain of Newcastle disease virus (NDV) has been determined. The L gene is 6704 nucleotides long and encodes a protein of 2204 amino acids with a calculated molecular weight of 248822. Mung bean nuclease mapping of the 5' terminus of the L gene mRNA indicates that the transcription of the L gene is initiated 11 nucleotides upstream of the translational start site. Comparison with the amino acid sequences of the L genes of Sendai virus and vesicular stomatitis virus (VSV) suggests that there are several regions of homology between the sequences. These data provide further evidence for an evolutionary relationship between the Paramvxoviridae and the Rhabdoviridae. A non-coding sequence of 46 nucleotides downstream of the presumed polyadenylation site of the L gene may be part of a negative strand leader RNA.


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