Skip Navigation

This Article
Right arrow Print PDF (1834K)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (13)
Right arrowRequest Permissions
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Fujita, A.
Right arrow Articles by Sakaki, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fujita, A.
Right arrow Articles by Sakaki, Y.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1987, Vol. 15, No. 10 4007-4020
© 1987

Articles

The L1 family (Kpnl family) sequence near the 3' end of human ß-globin gene may have been derived from an active L1 sequence

Atsushi Fujita, Masahira Hattori, Osamu Takenaka+ and Yoshiyuki Sakaki

Research Laboratory for Genetic Information, Kyushu University 18 3-1-1 Maidashi, Higashi-ku, Fukuoka 812, Japan +Primate Institute, Kyoto University Inuyama, Aichi 484, Japan

Received February 27, 1987. Revised April 24, 1987. Accepted April 24, 1987.

We previously reported that some L1 family (Kpnl family) members are closely associated with the Alu family sequence. To understand the details of the Ll-Alu association, the structure of a Ll-Alu unit downstream from the ß-globin gene was compared between human and primates. The results revealed that the L1-Alu-associated sequence was formed by the insertion of the L1 sequence, TBG41, into the 3' poly A tract of the preexisting Alu family sequence. It was estimated that the TßG41 sequence was inserted after the divergence of Old World monkeys and hominoids and before the divergence of orang-utan and common ancestor of other higher hominoids. From the calculation of the mutation rates of L1 sequences, it was suggested that the TßG41 was derived from an active L1 sequence which was able to encode reverse transcriptase-related protein.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.