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Nucleic Acids Research, 1987, Vol. 15, No. 10 4123-4130
© 1987

Articles

A new ‘sense’ RNA approach to block viral RNA replication in vitro

M.D. Morch, R.L. Joshi, T.M. Denial and A.L. Haenni

Laboratoire de Biochimie du Développement, Institut Jacques Monod, CNRS-Université Paris VII 2 Place Jussieu, 75251 Paris Cedex 05, France

Received March 18, 1987. Accepted April 24, 1987.

The use of "antisense" RNA is being widely considered to block specific steps in viral infection. We propose here a new "sense" RNA approach to block viral RNA replication in vitro and possibly in vivo. In the turnip yellow mosaic virus (TYMV) system, the recognition site of the viral replicase (RNA-dependent RNA polymerase) is assumed to be located within the 3' end of the RNA genome. Small "sense" RNAs have been obtained by in vitro transcription of the corresponding cloned cDNAs. Replication of TYMV RNA in vitro is shown here to be blocked only by those RNAs that contain the 3' terminal region of the genome.


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