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Nucleic Acids Research, 1987, Vol. 15, No. 10 4337-4347
© 1987

Articles

Isolation and characterization of the gene for the murine T cell differentiation antigen and immunoglobulin-related molecule, Lyt-2

Hiromitsu Nakauchi1, Masatoshi Tagawa, Garry P. Nolan and Leonard A. Herzenberg2

Department of Genetics, Stanford University Stanford, CA 94305, USA

Received December 16, 1986. Revised April 20, 1987. Accepted April 20, 1986.

We present here the sequence of the 5310 base pair Hind III-cleaved genomic DNA segment that includes the gene for the Lyt-2, a murine differentiation antigen expressed on most immature T lymphocytes as well as the cytotoxic suppressor T cell subset. We also present the complete intron/exon structure of Lyt-2. There are five exons: a fused leader and immunoglobulin variable region like exon, a hinge region exon, a transmembrane exon and two alternatively spliced intracytoplasmic exons (alternative splicing of these exons yields the 38 kDa alpha Lyt-2 and 34 kDa alpha' Lyt-2 polypeptides). The promoter region contains a "TATA" box and sequences homologous to the putative immunoglobulin transcriptional control elements cd/pd. S1 protection analysis reveals that thymocytee, T cells from lymph nodes, and a Lyt-2 transfectant obtained by introduction of total genomic DNA have the same initiation site. In the 3' region, there is a polyadenylation signal sequence after a 700 bp long 3' untranslated region.

1Present address: Department of Immunology, Juntendo University, Tokyo 113, Japan


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