Skip Navigation

This Article
Right arrow Print PDF (8673K)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (60)
Right arrowRequest Permissions
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Nechushtan, H.
Right arrow Articles by Reshef, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nechushtan, H.
Right arrow Articles by Reshef, L.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1987, Vol. 15, No. 16 6405-6417
© 1987

Articles

Glucocorticoids control phosphoenolpyruvate carboxykinase gene expression in a tissue specific manner

Hovav Nechushtan, Nissim Benvenisty, Ruth Brandeis and Lea Reshef*

Department of Developmental Biochemistry, Institute of Biochemistry, Hebrew University—Hadassah Medical School Jerusalem 91010, Israel

*To whom correspondence should be addressed

Received May 14, 1987. Revised July 29, 1987. Accepted July 29, 1987.

Cytosolic Phosphoenolpyruvate carboxykinase is a key gluconeogenic enzyme which is expressed in a tissue specific manner in the liver, kidney and adipose tissue and is under hormonal control. The effect of glucocorticoids on expression of the gene coding for phosphoenolpyruvate carboxykinase in adipose tissue has been studied in vivo in rats and in vitro in adipose tissue organ culture and mouse 3T3 L1 adipocytes. Glucocorticoids, both in vivo and in vitro, repress the steady state level of phosphoenolpyruvate carboxykinase mRNA in the adipose tissue while increasing it in the kidney. The size of the mRNA and its 5' end are identical in adipose tissue and kidney, thus the same promoter is used in all tissues. The inhibitory effect of glucocorticoids on phosphoenolpyruvate carboxykinase gene expression was located at the level of transcription. As glucocorticoids are known to stimulate transcription of phosphoenolpyruvate carboxykinase gene in the liver and kidney, the inhibitory effect on its transcription in adipose tissue suggests that tissue specific transcription factors may modulate the effect of glucocorticoids.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
J. Yang, X. Kong, M. E. S. Martins-Santos, G. Aleman, E. Chaco, G. E. Liu, S.-Y. Wu, D. Samols, P. Hakimi, C.-M. Chiang, et al.
Activation of SIRT1 by Resveratrol Represses Transcription of the Gene for the Cytosolic Form of Phosphoenolpyruvate Carboxykinase (GTP) by Deacetylating Hepatic Nuclear Factor 4{alpha}
J. Biol. Chem., October 2, 2009; 284(40): 27042 - 27053.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
Z. Michailidou, A. P Coll, C. J Kenyon, N. M Morton, S. O'Rahilly, J. R Seckl, and K. E Chapman
Peripheral mechanisms contributing to the glucocorticoid hypersensitivity in proopiomelanocortin null mice treated with corticosterone
J. Endocrinol., July 1, 2007; 194(1): 161 - 170.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Cassuto, K. Kochan, K. Chakravarty, H. Cohen, B. Blum, Y. Olswang, P. Hakimi, C. Xu, D. Massillon, R. W. Hanson, et al.
Glucocorticoids Regulate Transcription of the Gene for Phosphoenolpyruvate Carboxykinase in the Liver via an Extended Glucocorticoid Regulatory Unit
J. Biol. Chem., October 7, 2005; 280(40): 33873 - 33884.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. Reshef, Y. Olswang, H. Cassuto, B. Blum, C. M. Croniger, S. C. Kalhan, S. M. Tilghman, and R. W. Hanson
Glyceroneogenesis and the Triglyceride/Fatty Acid Cycle
J. Biol. Chem., August 15, 2003; 278(33): 30413 - 30416.
[Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Olswang, B. Blum, H. Cassuto, H. Cohen, Y. Biberman, R. W. Hanson, and L. Reshef
Glucocorticoids Repress Transcription of Phosphoenolpyruvate Carboxykinase (GTP) Gene in Adipocytes by Inhibiting Its C/EBP-mediated Activation
J. Biol. Chem., April 4, 2003; 278(15): 12929 - 12936.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
S. Franckhauser, S. Munoz, A. Pujol, A. Casellas, E. Riu, P. Otaegui, B. Su, and F. Bosch
Increased Fatty Acid Re-esterification by PEPCK Overexpression in Adipose Tissue Leads to Obesity Without Insulin Resistance
Diabetes, March 1, 2002; 51(3): 624 - 630.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
M. Diamond, J. Miner, S. Yoshinaga, and K. Yamamoto
Transcription factor interactions: selectors of positive or negative regulation from a single DNA element
Science, September 14, 1990; 249(4974): 1266 - 1272.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
D. W. Eubank, E. Duplus, S. C. Williams, C. Forest, and E. G. Beale
Peroxisome Proliferator-activated Receptor gamma and Chicken Ovalbumin Upstream Promoter Transcription Factor II Negatively Regulate the Phosphoenolpyruvate Carboxykinase Promoter via a Common Element*
J. Biol. Chem., August 3, 2001; 276(32): 30561 - 30569.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.