Nucleic Acids Research, 1987, Vol. 15, No. 16 6677-6690
© 1987
Articles |
A growth-related mRNA in cultured mouse cells encodes a placental calcium binding protein
Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University Evanston, EL 60201, USA
Received April 5, 1987. Revised July 29, 1987. Accepted July 29, 1987.
We have characterized an mRNA that increases in abundance after serum stimulation of quiescent mouse fibroblasts. This mRNA, designated 18A2, encodes a predicted polypeptide of 101 amino acids with homology to known calcium binding proteins. A variety of mouse tissues express the 18A2 mRNA, with the highest levels detected in the non-pregnant uterus and in the placenta. The concentration of 18A2 mRNA in total placental RNA decreases from day 8 to day 10 of pregnancy, and is below detection throughout the latter half of gestation. In serum-stimulated fibroblasts, the increase in 18A2 mRNA is dependent on protein synthesis. The 18A2 mRNA is similar in size, serum-inducibility, and sequence to the 2A9 mRNA (1), but these mRNAs are derived from distinct genes. This suggests that the mouse genome harbors a family of serum-inducible genes encoding proteins predicted to bind calcium.
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