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Nucleic Acids Research, 1987, Vol. 15, No. 18 7235-7248
© 1987

Articles

Solid phase synthesis of oligoribonucleotides using the o-nitrobenzyl group for 2'-hydroxyl protection and H-phosphonate chemistry

Toshiki Tanaka, Shigeru Tamatsukuri and Morio Ikehara

Faculty of Pharmaceutical Sciences, Osaka University Suita, Osaka 565, Japan

Received August 4, 1987. Accepted August 28, 1987.

Oligoribonucleotides with chain length of 7, 11, 15, 17, 24 and 34 were synthesized on long chain alkylamine controlled pore glass beads (LCA-CPG) using o-nitrobenzyl protection of 2'-hydroxyis via a H-phosphonate approach either manually or by using an automatic synthesizer. The oligoribonucleotides were obtained in yields of 0.6 – 20%, based on initial nucleoside bound to the LCA-CPG support.


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