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Nucleic Acids Research, 1987, Vol. 15, No. 18 7295-7308
© 1987

Articles

Molecular structure of the gene and the 5'-flanking region of the human lymphocyte immunoglobulin E receptor

Ueli Suter, Ricardo Bastos and Hans Hofstetter*

Department of Biotechnology, Ciba-Gcigy Ltd 4002 Basel, Switzerland

*To whom correspondence should be addressed

Received July 16, 1987. Accepted August 28, 1987.

Overlapping clones which contain the complete gene encoding the human lymphocyte IgE receptor (MW: 45kd; identical with CD23), were isolated from human genomic {lambda}-libraries. The gene spans approximately 13kb and comprises 11 exons. The 5'-end of the mRNA was mapped by primer extension and S1-mapping, revealing two initiation sites for transcription. Two corresponding TATA boxes were identified by sequencing the 5'-flanking region. A 188bp long inverted repeat was found which flanks the promoter region and could possibly be involved in gene regulation. Exons 9 to 11 code for the IgE-binding domain of the receptor which shows homology to several lectins, particularly to the asialoglycoprotein receptor. A comparison of the exon/intron arrangement of these genes implies that their leetin domains have evolved from a common ancestral cassette.


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