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Nucleic Acids Research, 1987, Vol. 15, No. 18 7343-7356
© 1987

Articles

Structure of the gene for human uroporphyrinogen decarboxylase

Marc Romana, Anne Dubart, Denise Beaupain, Claude Chabret, Michel Goossens and Paul-Henri Romeo*

INSERM U 91, CNRS EA 607, Hôpital Henri Mondor 94010 Créteil, France

*To whom correspondence should be addressed

Received July 9, 1987. Accepted August 27, 1987.

Uroporphyrinogen decarboxylase, the fifth enzyme of the heme biosynthetic pathway, is an housekeeping enzyme whose activity is enhanced during erythro-poietic differentiation. We have previously shown that this increased activity was in part accounted for by an enhanced transcription of the gene in erythropoietic tissues. To elucidate further the tissue specific regulation of an housekeeping gene we have isolated the human URO-D gene and determined its organization. The cloned gene comprises 10 exons spread over 3 Kb. Two transcriptional start sites were determined and analysis of 900 bp of the 5' flanking region suggests a very simple structural organization for the URO-D gene promoter. we also show that this gene is functional when transfected into mouse fibroblasts, and that its promoter is sensitive to a viral enhancer.


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