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Nucleic Acids Research, 1987, Vol. 15, No. 19 8057-8067
© 1987

Articles

The HLA-DQß gene upstream region contains an immunoglobulin-like octamer motif that binds cell-type specific nuclear factors

Kiyoshi Miwa* and Jack L. Strominger

Department of Biochemistry and Molecular Biology, Harvard University Cambridge, MA 02138, USA

Received June 23, 1987. Accepted September 2, 1987.

A method is described for scanning relatively large fragments of DNA for sequences which bind nuclear factors. This method was used to identify an octamer (ATTTGTAT) in the DQß gene upstream region which differs from the immunoglobulin gene octamer (ATTTGCAT) by only 1 bp. The DQß gene octamer binds two proteins, one (B2) appears to be B cell specific while the other (B1) is not. These factors are either similar or identical to factors which bind to the octamer motif in immunoglobulin genes. All other class II MHC genes for which sequence information is available contain an octamer motif in their upstream region. Thus, the possibility that these sequences regulate B cell specific expression of class II MHC genes requires careful evaluation.

*Present address: Central Research Laboratories, AJinomoto Company, Inc., Kawasaki 210, Japan


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