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Nucleic Acids Research, 1987, Vol. 15, No. 2 595-609
© 1987

Articles

The complete coding sequence of the human A-raf-1 oncogene and transforming activity of a human A-raf carrying retrovirus

T.W. Beck, M. Huleihel, M. Gunnell1, T.I. Bonner2 and U.R. Rapp

Laboratory of Viral Carcinogenesis, National Cancer Institute Frederick, MD 21701 1Program Resources Inc., Frederick Cancer Research Facility Frederick, MD 21701 2Laboratory of Cell Biology, National Institute of Mental Health Bethesda, MD 20205, USA

Received September 9, 1986. Revised December 5, 1986. Accepted December 5, 1986.

The complete 606 amino acid sequence of the human A-raf oncogene has been deduced from the 2453 nucleotide sequence of a human T cell cDNA. A cysteine-rich region located near the amino terminus, which is highly conserved in A-raf and c-raf. shows significant homology with protein kinase C. A 5' deleted fragment of the cDNA has been incorporated into a murine retrovirus which endows the virus with the ability to transform cells in vivo and in vitro. Functionally, human A-raf is similar to v-raf and v-mos in that transformation is independent of ras gene function.


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