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Nucleic Acids Research, 1987, Vol. 15, No. 20 8511-8519
© 1987

Articles

Selective catalysis of A-T base pair proton exchange in DNA complexes: imino proton NMR analysis

Lucjan Strekowski, Rebecca A. Watson and W.David Wilson

Department of Chemistry, Georgia State University Atlanta, GA 30303, USA

Received July 13, 1987. Revised September 25, 1987. Accepted September 25, 1987.

Polyaromatic molecules with amino chain substituents, upon binding with DNA, selectively catalyze exchange of the A.T base pair protons with bulk water protons. The amine-catalyzed exchange is mediated by compounds which are A.T and G.C base sequence specific, intercalators, and outside binders. A mechanism for the selective exchange, involving transient opening and closing of individual A.T base pairs in the duplex, is discussed.


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