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Nucleic Acids Research, 1987, Vol. 15, No. 21 8899-8918
© 1987

Articles

Supercoiled induced transition to the Z-DNA conformation affects the ability of a d(CG/GC)12 sequence to be organized into nucleosome-cores

J.M. Casasnovas and F. Azorin*

Grupo de Quimica Macromolecular, Centro de Investigacion y Desarrollo del CSIC ETSIIB, 08028 Barcelona, Spain

*To whom correspondence should be addressed

Received May 15, 1987. Revised August 25, 1987. Accepted September 25, 1987.

Nucleosome-cores were reconstituted by the salt-dialysis method onto closed circular pDHg16 DNA which contains a d(CG/GC)12 sequence. Alternating d(CG/GC)n sequences form left-handed Z-DNA readily when contained in negatively supercoiled DNA. We have investigated the ability of the d(CG/GC)12 sequence to be organized into nucleosome-cores when stabilized as Z-DNA through negative supercoiling. We have found that nucleosome assembly at the d(CG/GC)12 insert is prevented when the sequence 1s stable in the Z-conformation but it is not affected at all when the sequence adopts the right-handed B-form.


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