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Nucleic Acids Research, 1987, Vol. 15, No. 21 8919-8934
© 1987

Articles

Cloning and charaterization of a human ribosomal protein gene with enhanced expression in fetal and neoplastic cells

Jing-hsiung Ou*, T.S.Benedict Yen1, Yan-Fei Wang1, Wing K. Kam and William J. Rutter

Hormone Research Institute and Departments of Biochemistry and Biophysics, University of California San Francisco. CA 94143, USA 1Department of Pathology, University of California San Francisco, CA 94143, USA

Received May 5, 1987. Revised October 5, 1987. Accepted October 5, 1987.

Hepatocellular carcinoma is strongly associated with hepatitis B virus carrier patients who usually have HBV sequences integrated in the chromosomal DNA of liver cells. To assess the possible effects of HBV regulatory sequences (e.g., the enhancer) on expression of neighboring host genes we have screened for cellular genes that are both overexpressed and adjacent to integrated HBV sequences in hepatocellular carcinoma cells . The cloned cDNA for one such gene encodes a protein similar to the E. coli L-3 ribosomal protein which is thought to play a role in mRNA binding to the ribosome. The protein encoded by the cDNA localizes to the nucleolus and is also found in ribosomes; possibly it is the mammalian homologue of L-3 (MRL3). The expression of MRL3 is higher in colon carcinoma and lymphoma cell lines than in normal liver , placenta and diploid fibroblasts, and is also higher in fetal than in adult liver. Therefore, MRL3 overexpression seems to be a property of rapidly dividing cells and is not directly linked to oncogenesis.

*Present address: Department of Microbiology, University of Southern California School of Medicine, Los Angeles, CA 90033, USA


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