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Nucleic Acids Research, 1987, Vol. 15, No. 21 8957-8962
© 1987

Articles

Linkage of TNF genes to the HLA-B locus

Hidetoshi Inoko and John Trowsdale

Human Immunogenetics Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields London WC2A 3PX, UK

Received September 14, 1987. Accepted October 8, 1987.

pulsed field gel electrophoresis was used to determine the location of the tumour necrosis factor (TNF) {alpha} and ß genes. They vere shown to be linked to the HLA-B locus; analagous to their location in mouse, between the complement (class III) region and H-2D. However, the distance between the TNF genes and the class I region was much greater in man, namely about 260 kb, compared to 70 kb in the mouse. This finding may have implications for some HLA associated diseases.


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