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Nucleic Acids Research, 1987, Vol. 15, No. 21 9027-9042
© 1987

Articles

Isolation and characterization of a Neurospora crassa ribosomal protein gene homologous to CYH2 of yeast

Carol A. Kreader and Joyce E. Heckman

Department of Chemistry, Indiana University Bloomington, IN 47405, USA

Received July 24, 1987. Revised September 23, 1987. Accepted September 23, 1987.

We have isolated and characterized a Neurospora crassa gene homologous to the yeast CYH2 gene encoding L29, a cycloheximide sensitivity-conferring protein of the cytoplasmic ribosome. The cloned Neurospora gene was isolated by cross-hybridization to CYH2. It was sequenced from both cDNA and genomic clones. The coding region is interruptad by seven intervening sequences. Its deduced amino acid sequence shows 70% homology to that of yeast ribosomal protein L29 and 60% homology to that of mammalian ribosomal protein L27', suggesting that the protein has an important role in ribosomall function. The pattern of codon usage is highly biased, consistent with high translation efficiency. There is a single copy of this gene in N. crassa, and R. Metzenberg and coworkers have mapped its genetic location to the vicinity of the cyh-2 locus.


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