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Nucleic Acids Research, 1987, Vol. 15, No. 22 9195-9214
© 1987

Articles

Genomic characterization of the human DNA excision repair gene ERCC-1

Marcel van Duin, Marcel H.M. Koken, Jacolien van den Tol, Peter ten Dijke, Hanny Odijk, Andries Westerveld, Dirk Bootsma and Jan H.J. Hoeijmakers

Department of Cell Biology and Genetics, Erasmus University PO Box 1738, 3000 DR Rotterdam, The Netherlands

Received September 11, 1987. Accepted October 22, 1987.

In this report the genomic characterization of the human excision repair gene ERCC-1 is presented. The gene consists of 10 exons spread over approximately 15 kb. By means of a transfection assay the ERCC-1 promoter was confined to a region of ± 170 bp upstream of the transcriptional start site. Classical promoter elements like CAAT, TATA and GC-boxes are absent from this region. Furthermore, ERCC-1 transcription is not UV-inducible. A possible explanation is provided for the previously reported alternative splicing of exon VIII. Analysis of ERCC-1 cDNA clones revealed the occurrence of differential polyadenylation which gives ERCC-1 transcripts of 3.4 and 3.8 kb in addition to the major 1.1 kb mRNA. Apparent evolutionary conservation of differential polyadenylation of ERCC-1 transcripts suggests a possible role for this mode of RNA processing in the ERCC-1 repair function.


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