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Nucleic Acids Research, 1987, Vol. 15, No. 3 959-970
© 1987

Articles

Genetic organization of the c-sis transcription unit

Ans M.W. Van den Ouweland, Jan J.M. Van Groningen, Jack A. Schalken1, Han W. Van Neck, Henri P.J. Bloemers and Wim J.M. Van de Ven

Molecular Oncology Section, Department of Biochemistry, University of Nijmegen, Geert Grooteplein Noord 21 6525 EZ Nijmegen, The Netherlands 1Department of Urology, University of Nijmegen The Netherlands

Received November 11, 1986. Accepted January 8, 1987.

The structure and genetic organization of the transcription unit of the c-sis proto-oncogene was determined. Comparative nucleotide sequence analysis of the exon sequences of feline and human c-sis revealed a very high degree of homology. The cap site as well as the poly(A)-addition site of the sis transcript of each species was identified and found in similar positions. An insert of 4 amino acids was found In the deduced translational product of feline c-sis and It was located at the amino-terminus of the region that constituted the platelet-derived growth factor domain. An insert of 149 bp present at the 5' end of exon 7 of human c-sis but absent In the simian sarcoma virus v-sis oncogene was also present In the feline c-sis proto-oncogene.


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