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Nucleic Acids Research, 1987, Vol. 15, No. 7 3009-3022
© 1987

Articles

Nonrandom distribution of MMTV proviral sequences in the mouse genome

Julio Salinas, Marino Zerial*, Jan Filipski, Michel Crepin1 and Giorgio Bernardi+

Laboratoire de Génétique Moléculaire, Institut Jacques Monod 2 Place Jussieu, 75005 Paris 1Institut Pasteur 25 Rue du Docteur Roux, 75015 Paris, France

+To whom correspondence should be addressed

Received December 1, 1986. Revised March 3, 1987. Accepted March 3, 1987.

Integrated sequences of mouse mammary tumor virus (MMTV) have been localized in the genomes of five inbred mouse strains (Balb/c, C3H, DBA/2, A.TH, 129-SV) and one mammary tumor cell line (GR). Two major classes of MMTV sequences have been detected in mouse DNA fractions as obtained by CS2SO4/BAMD (3,6-bis-(acetatoraercurimethyl)dioxane) density gradient centrifugation. The first one corresponds to previously described endogenous sequences (Mtv loci), whereas the second one corresponds to endogenous sequences not previously known, and/or recently acquired; in the case of GR cells exogenous sequences may also be present in this class. The genome distribution is somewhat different for the two classes of sequences, the first one being practically only present in the lightest DNA segments of the mouse genome (GC~38%); the second one being also represented in heavier segments (GC~ 43%). This integration pattern suggests that "ancient" endogenous sequences are practically only localized in genome segments of roughly matching composition, whereas exogenous and recently acquired endogenous MMTV sequences may also be present in heavier fractions.

*Present address: EMBL, Postfach 10.2209, D-6900 Heidelberg, FRG


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