Nucleic Acids Research, 1987, Vol. 15, No. 8 3439-3453
© 1987
Articles |
The twist gene: isolation of a Drosophila zygotle gene necessary for the establishment of dorsoventral pattern
Laboratoire de Géoétique Moléculaire des Eucaryotes du CNRS, Unité184 de Biologic Moléculaire et de Géné de Géoé de I'INSERM, Faculté de Médecine 11 rue Humann, 67085 Strasbourg Cédex, France
Received February 16, 1987. Revised March 20, 1987. Accepted March 20, 1987.
The twist zygotic gene appears to be involved in the establishment of the dorso-ventral pattern in Drosophila embryos. Homozygous twist embryos are partially dorsalized, their gastrulation is abnormal, and they fail to differentiate mesoderm. We determined the temperature-sensitive period of twist around the gastrulation time, and we isolated the gene. A 300 kb chromosomic walk allowed the detection of the 70 kb deletion that delimits the twist region in Df(2R)twiS60. Southern blot analyses of 21 EMS induced twist allele ONAs and systematic Northern blot analyses all over this 70 kb region lead to the localization of the twist gene: within about 10 kb at the left border of the deletion, 2 twist alleles show each a small deletion that uncover a transcription unit whose expression occurs about at the time of gastrulation.
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