Skip Navigation

This Article
Right arrow Print PDF (3468K)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (112)
Right arrowRequest Permissions
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Westley, B. R.
Right arrow Articles by May, F. E.B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Westley, B. R.
Right arrow Articles by May, F. E.B.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1987, Vol. 15, No. 9 3773-3786
© 1987

Articles

Oestrogen regulates cathepsin D mRNA levels in oestrogen responsive human breast cancer cells

Bruce R. Westley and Felicity E.B. May

Department of Pathology, Royal Victoria Infirmary Queen Victoria Road, Newcastle upon Tyne NE1 4LP, UK

Received February 27, 1987. Revised April 6, 1987. Accepted April 6, 1987.

A cDNA library was constructed from the mRNA of the ZR-75 oestrogen responsive human breast cancer cell line and screened for oestrogen regulated mRNA sequences. Of the recombinants isolated, 30 contained cDNA that corresponded to a single mRNA species of 2.1 kb that was induced between 10 and 15 fold by oestradiol treatment. The sequence of the entire open reading frame and 3'non-coding region of the mRNA was determined and shown to encode the aspartyl protease cathepsin D. The induction of cathepsin D mRNA is specific for oestrogen and is maximal at 3 x 10–10 M. Cathepsin D mRNA levels were increased by oestrogen in 3 oestrogen responsive breast cancer cell lines. Cathepsin D mRNA was expressed but not regulated in an oestrogen receptor negative breast tumour cell line, BT 20, and in 2 other malignant cell lines, Hela and A431.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Mol. Endocrinol.Home page
A. K. Rao, Y. S. Ziegler, I. X. McLeod, J. R. Yates, and A. M. Nardulli
Effects of Cu/Zn Superoxide Dismutase on Estrogen Responsiveness and Oxidative Stress in Human Breast Cancer Cells
Mol. Endocrinol., May 1, 2008; 22(5): 1113 - 1124.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C. D. Curtis, V. S. Likhite, I. X. McLeod, J. R. Yates, and A. M. Nardulli
Interaction of the Tumor Metastasis Suppressor Nonmetastatic Protein 23 Homologue H1 and Estrogen Receptor {alpha} Alters Estrogen-Responsive Gene Expression
Cancer Res., November 1, 2007; 67(21): 10600 - 10607.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
D. V. Henley, N. Lipson, K. S. Korach, and C. A. Bloch
Prepubertal Gynecomastia Linked to Lavender and Tea Tree Oils
N. Engl. J. Med., February 1, 2007; 356(5): 479 - 485.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
M. Becker, A. Sommer, J. R. Kratzschmar, H. Seidel, H.-D. Pohlenz, and I. Fichtner
Distinct gene expression patterns in a tamoxifen-sensitive human mammary carcinoma xenograft and its tamoxifen-resistant subline MaCa 3366/TAM
Mol. Cancer Ther., January 1, 2005; 4(1): 151 - 170.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. ProteomicsHome page
M. Huber, I. Bahr, J. R. Kratzschmar, A. Becker, E.-C. Muller, P. Donner, H.-D. Pohlenz, M. R. Schneider, and A. Sommer
Comparison of Proteomic and Genomic Analyses of the Human Breast Cancer Cell Line T47D and the Antiestrogen-resistant Derivative T47D-r
Mol. Cell. Proteomics, January 1, 2004; 3(1): 43 - 55.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. A. Zajchowski, K. Kauser, D. Zhu, L. Webster, S. Aberle, F. A. White III, H.-L. Liu, R. Humm, J. MacRobbie, P. Ponte, et al.
Identification of Selective Estrogen Receptor Modulators by Their Gene Expression Fingerprints
J. Biol. Chem., May 19, 2000; 275(21): 15885 - 15894.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.