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Nucleic Acids Research, 1987, Vol. 15, No. 9 3907-3916
© 1987

Articles

Influence of tetraalkyl ammonium lons on the structure of poly (rG-dC).poly (rG-dC): unexpected transitions among the Z, A and B conformations

Sumedha D. Jayasena and Michael J. Behe

Department of Chemistry, Lehigh University Bethlehem, PA 18015, USA

Received October 2, 1986. Revised April 9, 1987. Accepted April 9, 1987.

The conformation of the double-stranded, mixed ribo-deoxyribo polynucleotide, poly (rG-dC)•poly (rG-dC), has been examined in the presence of tetraalkyl ammonium ions. Tetramethyl ammonium ion stabilizes the "low salt" Z conformation (1) of the polymer from submillimolar to molar concentrations of the counterion. In the presence of tetraethyl and tetrapropyl ammonium ions the polymer exists in the low salt Z form up to 2 mM concentration of the counterions and then flips to the right hand helical A form. With tetrabutyl ammonium counterions the polymer is in an A conformation at low ion concentrations and converts to a B form at concentrations greater than thirty millimolar. These results are interpreted in terms of electrostatic and solvent interactions of the polynucleotide.


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