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Nucleic Acids Research, 1988, Vol. 16, No. 1 179-198
© 1988

Articles

Sequence and properties of the message encoding Tetrahymena hv1, a highly evolutionarily conserved histone H2A variant that is associated with active genes

Elizabeth M. White, Donald L. Shapiro1, C.David Allis2 and Martin A. Gorovsky

Department of Biology, University of Rochester Rochester, NY 14627 1Department of Pediatrics, University of Rochester School of Medicine and Dentistry Rochester, NY 14627 2Verna and Marrs McLean, Department of Biochemistry, Baylor College of Medicine Houston, TX 77030, USA

Received September 14, 1987. Revised November 10, 1987. Accepted November 10, 1987.

hv1 is a histone H2A variant found in the transcriptionally active Tetrahymena macronucleus, but not in the transcriptionally inert micronucleus. hv1 also contains antigenic determinants conserved in the histone complements of representatives of all four eukaryotic kingdoms. A cDNA clone encoding hv1 has been isolated and sequenced. Comparison of the derived protein sequence of hv1 with that of the chicken variant H2A.F and the sea urchin variant H2A.F/Z reveals remarkable homology in all but the extreme amino- and carboxy-termini and a small region in the conserved core. Putative regions of conserved antigenicity are discussed. Evidence is presented that suggests that hv1 is a single-copy, introncontaining gene that encodes a polyadenylated message. Unusual features in the 3' flanking sequence and in codon usage are also described. Evidence is also presented showing that hv1 message amounts are ten-fold greater in growing cells than in starved cells.


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