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Nucleic Acids Research, 1988, Vol. 16, No. 1 251-264
© 1988

Articles

Alternative use of chromosome fragmentation sites in the ciliated protozoan Oxytricha nova

Lawrence A. Klobutcher*, Martha E. Huff and Gregory E. Gonye

Department of Biochemistry, University of Connecticut Health Center Farmington, CT 06032, USA

*To whom correspondence should be addressed

Received August 24, 1987. Revised November 22, 1987. Accepted November 22, 1987.

During its life cycle, the hypotrichous ciliated protozoan Oxytricha nova transforms a copy of its micronucleus, which contains chramosomesized DNA, into a macronucleus containing linear, gene-sized DNA molecules. A region of the micronuclear genome has been defined that gives rise to two distinct macronuclear DNA molecules during development. Through analysis of recombinant macronuclear and micronuclear clones, the generation of the two macronuclear DNA molecules was shown to be the result of alternative use of chromosome fragmentation sites. In addition, evidence was obtained that adjacent micronuclear precursors of macronuclear DNA molecules can overlap by a few base pairs. The significance of these findings in relation to developmental chromosome fragmentation is discussed.


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