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Nucleic Acids Research, 1988, Vol. 16, No. 10 4197-4216
© 1988

Articles

The molecular structure of hop latent viroid (HLV), a new viroid occurring worldwide in hops

Holger Puchta, Karla Ramm and Heinz L. Sänger

Max-Planck-Institut f{euro}r Biochemie, Abteilung Viroidforschung D-8033 Martinsried bei M{euro}nchen, FRG

Received March 18, 1988. Revised April 18, 1988. Accepted April 18, 1988.

A new viroid which does not seem to produce any symptoms of disease, and is therefore tentatively named hop latent viroid (HLV) was found to occur worldwide in hops. HLV proved to be infectious when mechanically inoculated onto viroid- and virus-free hops. The viroid nature of HLV was also substantiated by sequence analysis which revealed that HLV is a circular RNA consisting of 256 nucleotides, that can be arranged into the viroid-specific, rod-like secondary structure. HLV also contains the central conserved region typical for most of the presently known viroids. However HLV does not contain the viroid-specific oligo(A) stretch in the upper left part of its rod-like molecule. Because of this feature and a sequence similarity with the prototypes of the other viroid groups below 55%, HLV can be regarded as the first member of a new viroid group.


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