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Nucleic Acids Research, 1988, Vol. 16, No. 10 4217-4223
© 1988

Articles

NCAM-180, the large isoform of the neural cell adhesion molecule of the mouse, is encoded by an alternatively spliced transcript

Dagmar Barthels, Gabriele Vopper and Wolfgang Wille

Instit{euro}t fur Genetik der Universitat zu Köln Weyertal 121, D-5000 Köln 41, FRG

Received March 17, 1988. Revised April 25, 1988. Accepted April 25, 1988.

The three different isoforms (NCAM–180, –140 and –120) of the murine neural cell adhesion molecule are encoded by a single gene. The two smaller isoforms, NCAM–120 and –140 are generated by alternative RNA splicing of the primary transcript. We here report sequence data of a mouse cDNA clone reverse transcribed from NCAM mRNA containing an extra fragment of 801 nt. This extra sequence is located within the coding region for the cytoplasmic domain of NCAM–140 and codes for additional 267 amino acids. We conclude that the sequence presented represents the 3' portion of the 7.4 kb NCAM transcript, which is also generated by alternative splicing. Thus, this sequence probably encodes NCAM–180, a polypeptide with a Mr of 117, 181.


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