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Nucleic Acids Research, 1988, Vol. 16, No. 10 4607-4620
© 1988

Articles

Synthesis of cyclic oligonucleotides by a modified phosphotriester approach

E. de Vroom, H.J.G. Broxterman, L.A.J.M. Sliedregt, G.A. van der Marel and J.H. van Boom

Gorlaeus Laboratory PO Box 9502, 2300 RA Leiden, The Netherlands

Received March 4, 1988. Revised April 15, 1988. Accepted April 15, 1988.

Evidence will be presented to show that the allyl group is suitable for the protection of a 3'-terminal phosphodiester function. The latter will be demonstrated by the synthesis, via a phosphotriester approach, of two cyclic tetraribonucleotides [r(AAAA) and r(UAMe2UAMe2)], two cyclic hexadeoxyribonucleotides [d(CGCGCG) and d(TAAAAA)] and a cyclic octadeoxyribonucleotide [d(CGTGCGTG)]


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