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Nucleic Acids Research, 1988, Vol. 16, No. 10 4651-4665
© 1988

Articles

Interruptions of (CG)n sequences by GG, TG and CA need not prevent B to Z transition in solution

Rakesh K. Mishra, P.K. Latha and Samir K. Brahmachari

Molecular Biophysics Unit, Indian Institute of Science Bangalore 560 012, India

Received January 20, 1988. Revised April 7, 1988. Accepted April 7, 1988.

Oligonucleotides containing alternating purines-pyrimidines with AT base pairs have been shown to exist in the Z-form preferably in solid state. We report that oligodeoxyribonucleotides with GG, TG and CA interruptions in their alternating CG sequences can undergo B to Z transition in solution in the absence of any chemical modification or topological constraint. The sequences, d(CGCGCGGCGCGC) and d(CGTGCGCACG) have been synthesised and shown to adopt Z- conformation in presence of millimolar concentrations of Ni2+ under low water activity conditions. Significance of GG, TG and CA interruptions in the B to Z transition is discussed.


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