Skip Navigation

This Article
Right arrow Print PDF (277K)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (41)
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Jinno, Y.
Right arrow Articles by Pastan, I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jinno, Y.
Right arrow Articles by Pastan, I.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1988, Vol. 16, No. 11 4957-4986
© 1988

Articles

A novel effect of EGF on mRNA stability

Yoshihiro Jinno, Glenn T. Merlino and Ira Pastan

Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health Building 37, Room 4E16, Bethesda, MD 20892, USA

Received December 30, 1987. Revised May 4, 1988. Accepted May 4, 1988.

Expression of the epidermal growth factor (EGF) receptor gene is stimulated by EGF and the phorbol ester, 4ß-phorbol 12-myristate 13-acetate (PMA). PMA elevates EGF receptor mRNA levels in human KB epidermoid carcinoma cells, but does not significantly affect the half-life of this mRNA when its decay is examined after the addition of actinomycin D. In contrast, EGF greatly prolongs the half-life of EGF receptor mRNA suggesting a possible mechanism for the stimulatory effect of EGF on EGF receptor mRNA levels. EGF also stabilizes ß-tubulin and ß-actin mRNAs but has very little effect on the degradation of total mRNA.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Reproductive SciencesHome page
B. Scoccia, Y. Mi Lee, C. Niederberger, and J. V. Ilekis
Expression of the ErbB Family of Receptors in Ovarian Cancer
Reproductive Sciences, May 1, 1998; 5(3): 161 - 165.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
G. Nicolini, M. Miloso, M. Moroni, L. Beguinot, and L. Scotto
Post-transcriptional Control Regulates Transforming Growth Factor alpha in the Human Carcinoma KB Cell Line
J. Biol. Chem., November 22, 1996; 271(47): 30290 - 30296.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. C. Johnson and A. C. Johnson
Activation of Epidermal Growth Factor Receptor Gene Transcription by Phorbol 12-Myristate 13-Acetate Is Mediated by Activator Protein 2
J. Biol. Chem., February 9, 1996; 271(6): 3033 - 3038.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. B. Montgomery, J. Guzman, D. M. O'Rourke, and W. L. Stahl
Expression of Oncogenic Epidermal Growth Factor Receptor Family Kinases Induces Paclitaxel Resistance and Alters beta -Tubulin Isotype Expression
J. Biol. Chem., June 2, 2000; 275(23): 17358 - 17363.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.