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Nucleic Acids Research, 1988, Vol. 16, No. 11 5169-5173
© 1988

Articles

Statistical method for rapid homology search

Andrey A. Mironov and Nickcolay N. Alexandrov

Institute for Genetics of Microorganisms 1-st Dorozhny pr. 1, Moscow 113545, USSR

Received July 28, 1987. Revised May 4, 1988. Accepted May 4, 1988.

A new method for homology search of DNA sequences is suggested. This method may be used to find extensive and not strong homologies with point mutations and deletions. The running program time for comparing sequences is less then the dynamic program algorithms at least at two orders of magnitude. It makes possible to use the method for homology searching throughover the nucleotide bank by personal computers.


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