Skip Navigation

This Article
Right arrow Print PDF (730K)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (57)
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by van Duin, M.
Right arrow Articles by Hoeijmakers, J.H.J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by van Duin, M.
Right arrow Articles by Hoeijmakers, J.H.J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1988, Vol. 16, No. 12 5305-5322
© 1988

Articles

Evolution and mutagenesis of the mammalian excision repair gene ERCC-1

M. van Duin, J. van den Tol, P. Warmerdam, H. Odijk, D. Meijer, A. Westerveld, D. Bootsma and J.H.J. Hoeijmakers

Department of Cell Biology and Genetics, Erasmus University PO Box 1738, 3000 DR Rotterdam, The Netherlands

Received April 7, 1988. Revised May 19, 1988. Accepted May 19, 1988.

The human DNA excision repair protein ERCC-1 exhibits homology to the yeast RAD10 repair protein and its longer c-terminus displays similarity to parts of the E.coli repair proteins uvrA and uvrC. To study the evolution of this ‘mosaic’ ERCC-1 gene we have isolated the mouse homologue. Mouse ERCC-1 harbors the same pattern of homology with RAD10 and has a comparable C-terminal extension as its human equivalent. Mutation studies show that the strongly conserved C-terminus is essential in contrast to the less conserved N-terminus which is even dispensible. The mouse ERCC-1 amino acid sequence is compatible with a previously postulated nuclear location signal and DNA-binding domain. The ERCC-1 promoter harbors a region which is highly conserved in mouse and man. Since the ERCC-1 promoter is devoid of all classical promoter elements this region may be responsible for the low constitutive level of expression in all mouse tissues and stages of embryogenesis examined.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
O. V. Tsodikov, J. H. Enzlin, O. D. Scharer, and T. Ellenberger
Crystal structure and DNA binding functions of ERCC1, a subunit of the DNA structure-specific endonuclease XPF-ERCC1
PNAS, August 9, 2005; 102(32): 11236 - 11241.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
P.-H. L. Gaillard and R. D. Wood
Activity of individual ERCC1 and XPF subunits in DNA nucleotide excision repair
Nucleic Acids Res., February 15, 2001; 29(4): 872 - 879.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
W. L. de Laat, E. Appeldoorn, N. G. J. Jaspers, and J. H. J. Hoeijmakers
DNA Structural Elements Required for ERCC1-XPF Endonuclease Activity
J. Biol. Chem., April 3, 1998; 273(14): 7835 - 7842.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
R. Perfetti, W. Lee-Kwon, C. Montrose-Rafizadeh, and M. Bernier
Overexpression and Activation of the Insulin Receptor Enhances Expression of ERCC-1 Messenger Ribonucleic Acid in Cultured Cells
Endocrinology, May 1, 1997; 138(5): 1829 - 1835.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.