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Nucleic Acids Research, 1988, Vol. 16, No. 12 5379-5390
© 1988

Articles

At least three human homeoboxes on chromosome 12 belong to the same transcription unit

Antonio Simeone, Maria Pannese, Dario Acampora, Maurizio D'Esposito and Edoardo Boncinelli*

International Institute of Genetics and Biophysics CNR, Via Marconi 10, 80125 Naples, Italy

*To whom correspondence should be addressed

Received March 30, 1988. Accepted May 19, 1988.

Mammalian homeoboxes show a clustered chromosomal organization. In the mouse, at least seven homeoboxes on chromosome 6 and at least six on chromosome 11 identify the murine Hox-1 and Hox-2 loci, respectively. A number of homeoboxes on chromosome 7 define the human HOX-1 locus and homeoboxes on chromosome 17 define the human HOX-2 locus. We studied the genomic organization of three homeobox sequences of the HOX-3 locus on chromosome 12 and analyzed transcripts from this region. Structural characterization and sequencing of several cDNA clones reveal that the three homeobox sequences present in this chromosomal region identify a single transcription unit. Primary transcripts are alternatively processed to give mature messengers with a common 5' noncoding exon encoding different proteins containing one of the three homeodomains.


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