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Nucleic Acids Research, 1988, Vol. 16, No. 13 6085-6096
© 1988

Articles

Mutational analysis of the contribution of sequence motifs within the IgH enhancer to tissue specific transcriptional activation

J. Perez-Mutul, M. Macchi and B. Wasylyk*

Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, Unité 184 de Biologie Moléculaire et de Génie Génétique de I'INSERM, Institut de Chimie Biologique, Faculté de Médecine 11 rue Hurnann, 67085 Strasbourg Cédex, France

*To whom correspondence should be addressed

Received April 29, 1988. Revised June 1, 1988. Accepted June 1, 1988.

We have investigated the role of sequence motifs in the immunoglobulin heavy chain (IgH) enhancer on its activity in myeloma and fibroblasts cell-lines. In transient transfection assays the transcription stimulatory activity of the enhancer is decreased in myeloma cells by mutating the E motifs 1, 2 and 3, the core motifs C1, C2, C3 and the octamer motif (0C) and in fibroblasts by mutating E2, E3, and C2. Our results suggest that transcription factors binding to El, C1, C3 and 0C contribute in a positive manner to the tissue specificity of the IgH enhancer.


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