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Nucleic Acids Research, 1988, Vol. 16, No. 14 6713-6724
© 1988

Articles

The intron requirement for immunoglobulin gene expression is dependent upon the promoter

Michael S. Neuberger and Gareth T. Williams

Medical Research Council Laboratory of Molecular Biology Hills Road, Cambridge, CB2 2QH, UK

Received May 17, 1988. Revised June 20, 1988. Accepted June 20, 1988.

Transfection assays were used to assess the need for an intron in order to obtain expression of cytoplasmic immunoglobulin µ mRNA. An intron is required when transcription is driven by an immunoglobulin promoter/enhancer combination, although this requirement is not specific for a particular intron. However, this need for an intron is dependent upon the promoter used. Whilst an intron is required in the case of immunoglobulin or ß-globin promoters, it is not in the case of cytomegalovirus or heat-shock promoters. The data point to a connection between the promoter and RNA processing or export.


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