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Nucleic Acids Research, 1988, Vol. 16, No. 15 7241-7251
© 1988

Articles

Insertion of a retrotransposon within the 3' end of a mouse gene provides a new functional polyadenylation signal

Thomas Baumruker, Claudia Gehe and Ivan Horak*

Institut für Virologie und Immunbiologie der Universität Wurzburg Versbacher Str. 7, 8700 Würzburg, FRG

*To whom correspondence should be addressed

Received June 9, 1988. Accepted June 29, 1988.

A site of genomic insertion of the mouse retrotransposon LTR-IS/MuRRS was analysed. The comparison of the genomic and the cDNA clones indicates the insertion of the LTR-IS element into the 3' untranslated region of a mouse gene. The fact that the isolated cDNA clone ends with a poly A tail 20 nucleotides down-stream from the LTR-IS AATAAA box and the result of the Slnuclease mapping provides evidence that the 3' end of the mouse gene transcript was generated under the control of the LTR-IS polyadenylation signal.


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