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Nucleic Acids Research, 1988, Vol. 16, No. 15 7287-7301
© 1988

Articles

Identification of two factors which bind to the upstream sequences of a number of nuclear genes coding for mitochondrial proteins and to genetic elements important for cell division in yeast

J. C. Dorsman, W. C. van Heeswijk and L. A. Grivell

Section for Molecular Biology, Department of Molecular Cell Biology Kruislaan 318, 1098 SM Amsterdam, The Netherlands

Received June 3, 1988. Accepted July 14, 1988.

Two abundant factors, GFI and GFII which interact with the 5' flanking regions of nuclear genes coding for proteins of the rnltochondrlal respiratory chain have been identified. In one case (subunit VIII of OH2 cytochrome c oxidoreductase) the binding sites for both factors overlap completely and their binding is mutually exclusive. For the other 5' regions tested the GFI and GFII binding sites do not coincide. Interestingly, binding sites for GFI and GFII are also present in or at the 3' ends of the coding regions of two genes of the PHO gene family and in DNA elements important for optimal ARS and CEN function respectively. The sites recognized by GFI conform to the consensus RTCRNNNNNNACGNR. while those recognized by GFII contain the element RTCACGTG. We speculate that GFI and GFII may play a role in different cellular processes, dependent on the context of their binding sites and that one of these processes may be the coordination of the expression of genes involved in mitochondrial biogenesis with the progress of the cell cycle.


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